王瑞达

王瑞达，男，中共党员，副教授，研究生学历，理学博士。

主要研究方向：放线菌代谢调控与合成生物学

主要学术成果：

［1］ Ruida Wang, Lei Chen, Jiaqi Zhao, Yu Gao, Tianyu Zhou, Jiang Ye*, Haizhen Wu*, Huizhan Zhang. MarR family regulator LcbR2 activates lincomycin biosynthesis in multiple ways. International Journal of Biological Macromolecules. 2025, 300:140292.

［2］Tianyu Zhou, Ruida Wang*, Wenli Jiang, Jiaqi Zhao, Jiang Ye, Haizhen Wu*, Huizhan Zhang. The protocatechuic acid catabolism regulator PcaV inhibits lincomycin biosynthesis either directly or indirectly through the control of the expression of other regulatory or metabolic gene. International Journal of Biological Macromolecules. 2025, 311:143649.

［3］ Tianyu Zhou, Yuan Cao, Zhicheng Zhang, Jing Shi, Huiming Ge, Faliang An, Jiang Ye, Ruida Wang*,  Haizhen Wu*. Fermentation Optimization of Loonamycin Production by Marine Nocardiopsis flavescens. Journal of Basic Microbiology. 2025, 65(6): e70012.

［4］ Yue Mao, Xianyan Zhang, Tianyu Zhou, Bingbing Hou, Jiang Ye, Haizhen Wu*, Ruida Wang*, Huizhan Zhang. Three new LmbU targets outside lmb cluster inhibit lincomycin biosynthesis in Streptomyces lincolnensis. Microbial Cell Factories. 2024, 23:3.

［5］Ruida Wang, Jiaqi Zhao, Lei Chen, Jiang Ye*, Haizhen Wu*, Huizhan Zhang. LcbR1, a newly identified GntR family regulator, represses lincomycin biosynthesis in Streptomyces lincolnensis. Applied Microbiology and Biotechnology. 2023, 107(24):7501-7514.

［6］ Ruida Wang, Tianyu Zhou, Fanjing Kong, Bingbing Hou, Jiang Ye*, Haizhen Wu*, Huizhan Zhang. AflQ1-Q2 represses lincomycin biosynthesis via multiple cascades in Streptomyces lincolnensis. Applied Microbiology and Biotechnology. 2023, 107(9):2933-2945.

［7］Jingyun Zou#, Yue Mao#, Bingbing Hou, Yajing Kang, Ruida Wang*, Haizhen Wu*, Jiang Ye, Huizhan Zhang. DeoR regulates lincomycin production in Streptomyces lincolnensis. World Journal of Microbiology and Biotechnology. 2023, 39(12):332.

［8］ Yu-Xi Jiang#, Gao-Fan Zheng#, Long-Chao Chen, Na Yang, Xiu-Juan Xin, Jun-Ying Ma, Jian-Hua Ju, Hui Wu, Ming Zhao, Ruida Wang*, Fa-Liang An*. Efficient ilamycins production utilizing Enteromorpha prolifera by metabolically engineered Streptomyces atratus. Biotechnology for Biofuels and Bioproducts. 2023, 16:151.

［9］Ruida Wang, Yuan Cao, Fanjing Kong, Bingbing Hou, Jiaqi Zhao, Yajing Kang, Jiang Ye*, Haizhen Wu*, Huizhan Zhang. Developmental regulator RamRsl controls both morphological development and lincomycin biosynthesis in Streptomyces lincolnensis. Journal of Applied Microbiology. 2022, 133(2):400-409.

［10］ Ruida Wang, Fanjing Kong, Haizhen Wu, Bingbing Hou, Yajing Kang, Yuan Cao, Shiwei Duan, Jiang Ye*, Huizhan Zhang*. Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction. Synthetic and Systems Biotechnology. 2020, 5(2):37-48.

主持在研课题：

1. 国家自然科学基金青年基金（C）项目，高效利用蔗糖的海洋链霉菌底盘构建与优化，42406126，202501-202712，经费30万元

2. 塔里木大学校长基金胡杨英才-引进人才科研启动金(博士)项目，链霉菌TRM15522果糖代谢调控机制研究与果糖诱导元件开发利用，TDZKBS202536，202505-202805，经费40万元

邮箱：wrd@taru.edu.cn